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ImbTreeEntropy: An r package for building entropy-based classification trees on imbalanced datasets

For instance, in M1 macrophages, disrupted Golgi function compromises system Xc - delivery to the plasma membrane, thereby limiting cystine uptake, depleting glutathione, and sensitizing cells to ferroptosis (112)

Cellular GSH concentrations are highly dependent on the availability of cysteine, which is the limiting precursor in GSH synthesis (Tateishi et al., 1974

However, next to the lower blood Tyr levels due to impaired conversion of Phe into Tyr, Phe has a high affinity for the large neutral amino acid (LNAA) transporter, compromising transport of all LNAAs over the blood-brain barrier (BBB), resulting in a reduction of neurotransmitter production [15, 17, 18]

Their dietary B12 intake is already limited to fortified foods and supplements